Ana Mª Guardiola – Página 43

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So far Ana Mª Guardiola has created 245 blog entries.

Topoisomerase II-Alpha gene copy number alterations in ERBB2-Positive primary breast carcinomas: A fluorescence in situ hybridization study

A Colomer¹, N Erill¹, M Górriz^1,2, M Verdú², R Roman¹, R Ibáñez¹, C Cordon-Cardo¹ and X Puig^1,2.

¹BIOPAT. Biopatologia Molecular, SL, Grup Assistència, Barcelona, Spain and ²Histopat Laboratoris, Barcelona, Spain.

Background: Topoisomerase II-alpha gene (TOP2A) aberrations have been recently pointed as predictive markers of anthracycline-based adjuvant chemotherapy in breast cancer. While coamplification of ERBB2 and TOP2A seems […]

Ana Mª Guardiola 2007-03-23T17:36:46+00:00

Genetic alterations of the epidermal growth factor receptor pathway in a series of non-small cell lung cancer characterized by morphology and immunophenotype

Verdú M,¹ Colomer A,¹ Erill N,¹ Roman R,² Górriz M, ^1,2Ibáñez R,¹ Cordon-Cardo C,¹ Puig X.^1,2

¹HISTOPAT Laboratoris, Barcelona, Catalonia, Spain &²BIOPAT. Biopatologia Molecular, Grup Assistència.

Background: Non-small cell lung cancer (NSCLC) is classified in two main categories: adenocarcinoma (AC), which includes bronchioloalveolar carcinoma (BAC), and squamous cell carcinoma (SCC). Activating mutations and increased copy […]

Ana Mª Guardiola 2006-09-23T17:54:01+00:00

A population study on the UGT1A1*28 variant associated to Irinotecan tolerance

Roman R,¹ Colomer A,¹ Erill N,¹ Verdú M,² Ibáñez R,¹ Cordon-Cardo C,¹ Puig X.^1,2

¹BIOPAT. Biopatologia Molecular, Grup Assistència & ²HISTOPAT Laboratoris, Barcelona, Catalonia, Spain.

Background: Irinotecan (CPT-11) is currently used as first- or second-line treatment for colorectal cancer, either alone or in combination with 5-fluorouracil based regimens. UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the inactivation of SN-38, the […]

Ana Mª Guardiola 2006-09-23T17:11:42+00:00

Tumores del estroma gastrointestinal: mutaciones en los genes KIT y PDGFRA

Los tumores del estroma gastrointestinal (GIST) son neoplasias de baja incidencia localizadas mayoritariamente en la pared gástrica (60%) o en el intestino delgado (25%), cuyo origen reside en las células intersticiales de Cajal, reguladoras de la motilidad del tubo digestivo. Las opciones terapéuticas disponibles en el caso de los GIST con potencial agresivo – alrededor […]

Ana Mª Guardiola 2006-03-25T16:35:04+00:00

Epidermal growth factor receptor in non small cell lung cancer: Gene copy number and mutational study

Colomer A¹, Erill N¹, Verdú M², Román R ¹, Górriz M², Ibáñez R¹, Menoyo A¹, Cordon-Cardo C³, Puig X ^1,2.

¹BIOPAT, Grup Assistència, ²HISTOPAT Laboratoris, Barcelona, Spain; and ³Division of Molecular Pathology, Memorial Sloan-Kettering Cancer Center, New York, United States.

Background: Activating mutations of the EGFR gene were identified in tumors from patients with non small cell […]

Ana Mª Guardiola 2006-02-23T17:52:21+00:00

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